Careers

Cell-line development and protein expression scientist
Position: The successful applicant will work as part of an interdisciplinary team of scientists discovering and developing the next generation of protein therapeutics for ophthalmic diseases, in particular retinal disorders. The position will use traditional and cutting-edge protein production systems to provide candidate therapeutic proteins for biological and biophysical characterization. In particular, the individual will have the ability to create cell lines from mammalian-cell production lines, such as CHO and HEK cells and bacterial-cell production systems, such as E. coli. Familiarity with transient transfections is required and experience with creating stable lines is preferred.

Requirements: A B.S. or M.S with 5 – 7 years or a Ph.D. with at least 2 years of post-graduate experience is required. Proficiency in protein expression in bacterial and mammalian systems (e.g. CHO and HEK), using transient transfection is required experience with generation of stable cell lines is preferred. Experience producing antibodies and FC- or Serum Albumin-fusion proteins is a plus. The successful applicant will be a highly motivated, creative individual with excellent verbal and written communication skills.

Protein Purification Scientist
Position: The successful applicant will work as part of an interdisciplinary team of scientists discovering and developing the next generation of protein therapeutics for ophthalmic diseases, in particular retinal disorders. purify candidate therapeutic proteins up to large scale (1 g) research use in formulation studies, chemical modification studies, and in vitro and in vivo biological characterization. The applicant may also contribute to developing biophysical characterization assays and protein formulation.

Requirements: A B.S. or M.S with 5 – 7 years or a Ph.D. in Biochemistry with at least 2 years of post-graduate experience is required. Proficiency in therapeutic protein purification at large research scales, including the requirements for use in vivo, particularly ophthalmic (intravitreal) administrations, such as reducing endotoxin levels. Candidate protein types include enzymes, Fc- or albumin-fusion proteins or antibodies. Familiarity with methods of chemical modification of proteins, such as PEGylation is preferred. Expertise with therapeutic protein biophysical characterization and formulation science is highly desirable. The successful applicant will be a highly motivated, creative individual with excellent verbal and written communication skills.

Protein Engineering Scientist
Position: The successful applicant will work as part of an interdisciplinary team of scientists discovering and developing the next generation of protein therapeutics for ophthalmic diseases, for example retinal disorders. In particular, this individual will be responsible for structure-based protein design and engineering of candidate therapeutic proteins, such as protein fusions and protein PEGylation, including use of relevant interdomain linker technologies, site specific design of protein sites for chemical modification, and use of domains for pharmacokinetic enhancement.

Requirements: A Ph.D. in Biochemistry with at least 2 years of post-graduate experience is required. Demonstrated experience in protein engineering techniques is required, such as basic computational assessment of domain structures for design into a therapeutic protein. The scientist will also have experience with design of genes for the therapeutic proteins and production in mammalian (e.g. CHO and HEK) and bacterial expression systems in sufficient quantity to evaluate the in vitro biological (cell-based and biochemical assays) and biophysical characteristics of the protein. Experience with developing assays (e.g. ELISAs) to assess drug levels and biomarkers in materials from in vivo studies is strongly preferred. The successful applicant will be a highly motivated, creative individual with excellent verbal and written communication skills.

Analytical Biochemist
Position: The successful applicant will work as part of an interdisciplinary team of scientists discovering and developing the next generation of protein therapeutics for ophthalmic diseases, in particular retinal disorders. The scientist will develop and evaluate methods to characterize candidate therapeutic proteins from the Mosaic drug delivery platform and potentially develop formulations for stabilization and use of the protein in vivo.

Requirements: A B.S. or M.S with 5 Р7 years or Ph.D. in Biochemistry with at least 2 years of post-graduate experience is required. Proficiency in protein analytical methods (MS; Size-exclusion, reverse phase, and ion exchange HPLC; DSC; ELISA for proteins) is required. Experience with development of therapeutic protein formulations is highly desirable. Experience with polymer analytical methods (GPC, rheology, viscosity measurements…) is highly desirable. The successful applicant will be a highly motivated, creative individual with excellent verbal and written communication skills.

To submit an application
Send an email to careers@mosaicbio.com with your resume  and cover letter.
Please reference the job title in the email subject line.