Pharmacology

Early PK/PD insight to avoid late-stage surprises

Mosaic integrates translational pharmacology into biologics discovery to support informed translational decisions and efficient in vivo study design.

Our pharmacology capabilities ensure candidates enter animal studies with appropriate exposure hypotheses and fit-for-purpose analytical support in place.

By embedding pharmacology alongside discovery and engineering, we reduce iteration cycles during preclinical development. Early pharmacology studies often follow cell-based assays used to evaluate functional activity during biologics discovery.

PK/PD and Bioanalytical Assays

Fit-for-purpose qualified assays to quantify pharmacokinetic and pharmacodynamic responses. These assays often complement protein sciences and analytics studies used to characterize biologic candidates.

Fit-for-purpose ELISA and ligand-binding assay development

Qualification of commercial or custom assays

Sample extraction and bioanalytical analysis

Tissue-specific method qualification

Biomarker quantification assays

Cross-reactivity and interference assessment

Study Support

Integrated support for translational pharmacology study design and interpretation. These studies often build on candidates generated through antibody discovery and optimization programs.

PK/PD protocol design and dose rationale

Sample processing and bioanalysis

Data visualization and PK/PD modeling

Translational pharmacology recommendations

From Study Design to Insight

1. PK/PD study design and assay strategy

2. Assay development and qualification

3. Study execution and sample analysis

4. Data interpretation and recommendations

Explore Mosaic’s full range of biologics discovery solutions supporting biologic discovery, engineering, and translational evaluation.

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Explore Other Discovery Solutions

Complementary capabilities supporting biologics discovery, engineering, and characterization.