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Protein Engineering Designed for Downstream Success

From sequence to structure to function, we design for efficacy and developability. 

Mosaic designs, engineers, and optimizes therapeutic proteins from early concept through candidate selection.

By combining computational design, diverse expression systems, and rigorous analytics, we deliver molecules that balance biological activity with manufacturability. Library-based protein engineering using yeast display is a core component of our platform, enabling affinity maturation, specificity refinement, and liability reduction through iterative, data-driven optimization.

Engineering decisions made early influence manufacturability, stability, and translational performance. Our workflows are designed to surface risk early and support confident progression.

Core Services

Design & Humanization

Computational modeling and humanization strategies that preserve function while improving developability and reducing immunogenicity risk.

Library-Based Protein Engineering (Yeast Display)

Library-based yeast display enables de novo discovery and iterative optimization of antibody and protein leads, supporting affinity maturation, specificity refinement, and reduction of developability liabilities.

Multispecifics & Bispecifics

Modular architectures, including common light chain approaches, supported by library-based engineering and yeast display, to build multispecific molecules with monoclonal-like manufacturability.

Expression & Purification

Platform-agnostic expression across bacterial, yeast, insect, and mammalian systems. Custom purification, refolding, and low-endotoxin preparation for in vivo use.

Bioconjugation & Glycoengineering

Site-specific modifications and tailored glycosylation strategies to tune PK/PD, targeting, and therapeutic index.

Developability & Optimization

Iterative engineering cycles—including library-based optimization via yeast display—to improve affinity, stability, solubility, and immunogenicity risk, supported by comprehensive biophysical characterization and early developability screening.

Expertise Across Modalities

Antibodies

Cytokines

Proteases

Soluble receptors

Engineered scaffolds

Typical timelines

At Mosaic, we combine scientific expertise, strategic planning, and collaborative execution to advance therapeutic programs efficiently and effectively.

2-3 months

  • Expression and purification

    ~ 4 weeks from gene synthesis

  • Engineering and optimization cycles

    ~ 2 weeks per cycle

  • Baseline developability package

    ~ 2 weeks

  • Library-based yeast display optimization campaigns

    ~ 3-4 months


Other solutions

Beyond this capability, Mosaic offers a full range of complementary discovery solutions designed to support every stage of biologic development.

Speak to a scientist

Connect with our discovery experts to discuss your program and explore how Mosaic can help move your ideas forward.

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